This could be caused by several reasons like an old version of Spybot-S&D, too much temporary files or problems with the system restore point.

In case you are using a dated version of Spybot-S&D, as a first solution, please download the latest version of Spybot - Search & Destroy, which should fix the problem. You will find links to several download locations on our homepage (online link). Do not forget to use the integrated update after installing Spybot-S&D.

If this does not help, please delete the contents of your Windows temp folder and try it again. Also, you might want to disable the Create system restore point when fixing spyware/usage tracks option on the settings page.